WarrZone 2002

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Wendy Warr has produced the following research papers in 2002.

Evaluation of an Experimental Chemistry Preprint Server

Wendy A. Warr

Paper given at the Sixth International Meeting on Chemical Structures, Noordwijkerhout, The Netherlands, June 2-6, 2002. Will appear in the March/April 2003 issue of J. Chem. Inf. Comput. Sci.

Abstract

A preprint is a research article made publicly available prior to formal publication. A preprint server is a freely available archive and distribution medium for preprints, allowing rapid dissemination, and use of multimedia and supporting files. Electronic eprints have been widely adopted in certain fields (notably high energy physics) but, until recently, the preprint concept has not been received with enthusiasm by most chemists. Despite the fact that preprints have the advantage of rapid publication, chemists have been reluctant to produce them because they could be viewed as “unallowable” for research assessment or tenure exercises or for publication in certain prestigious journals. In theory, preprints, together with version control and online discussion, could be a useful compromise: rapid pre-publication followed by open peer review, before publication in a traditional journal. This paper constitutes a preliminary evaluation of a Chemistry Preprint Server in its second year of operation and summarizes the lessons that can be learned from the experiment to date.

From Virtual Communities to Portals in the Post-Dotcom Era

Wendy A. Warr

In Proceedings of the 2002 International Chemical Information Conference; Collier, H., Ed.; Infonortics: Tetbury, 2002, pp. 113-126.

Abstract

“It is interesting to see that a subject area that a few years ago grew out of the unstructured worlds of chat and bulletin boards, is now finding such an important rôle in mainstream organisations and corporations. At last, organisations are finding that what was a fringe activity is rapidly becoming central to planning involving knowledge management with groups of staff or customers.”
Harry Collier, Infonortics, 2002

Are public virtual communities in the physical sciences (as opposed to corporate intranets) really coming of age? The start-up communities of 5 years ago still seem to attract members but there have been distinct changes. Are they indeed communities, or are they portals? Are they yet profitable? Will they ever be (indeed, need they be)? Have their business models changed? Have they become any more focused? Perhaps competition has appeared in the form of other services on the Net: how have the communities responded? Is there really any demand for the virtual community as dreamed of in the mid-1990s?

High Throughput Chemistry

Wendy A. Warr

Chapter 10.4.2 in Chemoinformatics - From Data to Knowledge Vol. 2, Advanced Topics. Gasteiger, J.; Engel, T. (Eds.), Wiley-VCH, New York, in press.

Contents

10.4.2.1 Introduction
10.4.2.2 History
10.4.2.3 Split and Mix Synthesis
10.4.2.3.1 Deconvolution
10.4.2.3.2 Encoded Libraries
10.4.2.4 Solid-phase Synthesis
10.4.2.4.1 Reviews of Chemistry
10.4.2.4.2 Natural Product Chemistry
10.4.2.4.3 Resins
10.4.2.4.4 Linkers
10.4.2.4.5 Microarrays
10.4.2.5 Solution-phase Synthesis
10.4.2.5.1 Polymer-Assisted Solution-Phase Synthesis
10.4.2.5.2 Fluorous Mixture Synthesis
10.4.2.6 Combinatorial Biosynthesis
10.4.2.7 Dynamic Combinatorial Chemistry
10.4.2.8 Laboratory Instrumentation
10.4.2.8.1 Microwave Synthesis
10.4.2.8.2 Purification and Analysis
10.4.2.9 Information Sources
10.4.2.10 Data Management
10.4.2.10.1 Library Registration
10.4.2.10.2 Research Asset Management and Inventory Control
10.4.2.11 Library Design
10.4.2.12 Virtual High Throughput Screening
10.4.2.13 Conclusion
References